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PDE2A Polyclonal Antibody

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PDE2A Polyclonal Antibody

Product Details

PD2A-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-

Fluorescence Resonance Energy Transfer (FRET)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to unique C-terminal amino acid sequence on PDE2A gene.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; PDE2A1; PDE2A2; PED2A4; phosphodiesterase 2A, cGMP-stimulated; unnamed protein product

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Gene Aliases: CGS-PDE; cGSPDE; IDDPADS; Pde2; PDE2A1; Pde2a2; PED2A4

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UniProt ID: (Human) O00408, (Mouse) Q922S4, (Rat) Q01062

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Entrez Gene ID: (Human) 5138, (Mouse) 207728, (Rat) 81743

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Function(s)
magnesium ion binding 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity zinc ion binding cAMP binding cGMP binding TPR domain binding phosphate ion binding identical protein binding protein homodimerization activity 3',5'-cyclic-GMP phosphodiesterase activity GAF domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter heart valve development ventricular septum development signal transduction adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of cGMP-mediated signaling regulation of mitochondrion organization monocyte differentiation aorta development cellular response to macrophage colony-stimulating factor stimulus negative regulation of vascular permeability positive regulation of vascular permeability cGMP catabolic process positive regulation of inflammatory response establishment of endothelial barrier cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to xenobiotic stimulus cellular response to transforming growth factor beta stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of cAMP/PKA signal transduction cellular response to 2,3,7,8-tetrachlorodibenzodioxine cardiac septum development cAMP catabolic process heart development negative regulation of signal transduction intracellular signal transduction coronary vasculature development cellular response to lipopolysaccharide negative regulation of oxidative phosphorylation negative regulation of nitric oxide-cGMP mediated signal transduction regulation of intracellular signal transduction response to hydrogen sulfide
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