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Fabgennix
PDE2A2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PD2A2-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; PDE2A; PDE2A1; PDE2A2; PED2A4; phosphodiesterase 2A, cGMP-stimulated; unnamed protein product
Gene Aliases: CGS-PDE; cGSPDE; IDDPADS; Pde2; PDE2A1; Pde2a2; PED2A4
UniProt ID: (Human) O00408, (Mouse) Q922S4, (Rat) Q01062
Entrez Gene ID: (Human) 5138, (Mouse) 207728, (Rat) 81743
magnesium ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
cAMP binding
cGMP binding
TPR domain binding
phosphate ion binding
identical protein binding
protein homodimerization activity
3',5'-cyclic-GMP phosphodiesterase activity
GAF domain binding
negative regulation of transcription from RNA polymerase II promoter
heart valve development
ventricular septum development
signal transduction
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of gene expression
negative regulation of cGMP-mediated signaling
regulation of mitochondrion organization
monocyte differentiation
aorta development
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cAMP
cellular response to cGMP
cellular response to xenobiotic stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
cardiac septum development
cAMP catabolic process
heart development
negative regulation of signal transduction
intracellular signal transduction
coronary vasculature development
cellular response to lipopolysaccharide
negative regulation of oxidative phosphorylation
negative regulation of nitric oxide-cGMP mediated signal transduction
regulation of intracellular signal transduction
response to hydrogen sulfide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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