Recommended positive controls: Jurkat cell extract.
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).
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Protein Aliases: cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited phosphodiesterase; Cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP-inhibited
Gene Aliases: A930022O17Rik; C87899; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; PDE3A; RNPDE3A