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Invitrogen
PDE3A Polyclonal Antibody
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Product Details
PA5-29481
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PDE3A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Pig (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP phosphodiesterase, myocardial cGMP-inhibited; cGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited cAMP phosphodiesterase; cGMP-inhibited phosphodiesterase; Cyclic GMP-inhibited phosphodiesterase A; phosphodiesterase 3A, cGMP-inhibited
Gene Aliases: A930022O17Rik; C87899; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; PDE3A
UniProt ID: (Human) Q14432, (Mouse) Q9Z0X4
Entrez Gene ID: (Human) 5139, (Mouse) 54611
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
estrogen receptor activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
estrogen binding
cAMP binding
phosphodiesterase
oocyte maturation
lipid metabolic process
signal transduction
G-protein coupled receptor signaling pathway
response to xenobiotic stimulus
cGMP-mediated signaling
intracellular steroid hormone receptor signaling pathway
regulation of meiotic nuclear division
negative regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of vascular permeability
oocyte development
positive regulation of oocyte development
regulation of ribonuclease activity
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
apoptotic signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cAMP catabolic process
cAMP-mediated signaling
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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