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Fabgennix
PDE3A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PD3A-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide selective only for PDE3A variants
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP phosphodiesterase, myocardial cGMP-inhibited; cGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited cAMP phosphodiesterase; cGMP-inhibited phosphodiesterase; cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP inhibited; phosphodiesterase 3A, cGMP-inhibited; unnamed protein product
Gene Aliases: A930022O17Rik; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; RNPDE3A
UniProt ID: (Human) Q14432, (Rat) Q62865, (Mouse) Q9Z0X4
Entrez Gene ID: (Human) 5139, (Rat) 50678, (Mouse) 54611
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
estrogen receptor activity
3',5'-cyclic-GMP phosphodiesterase activity
estrogen binding
cyclic-nucleotide phosphodiesterase activity
oocyte maturation
signal transduction
response to xenobiotic stimulus
intracellular steroid hormone receptor signaling pathway
regulation of meiotic nuclear division
negative regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of vascular permeability
positive regulation of oocyte development
regulation of ribonuclease activity
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
apoptotic signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
lipid metabolic process
G-protein coupled receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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