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Fabgennix
PDE3B Polyclonal Antibody
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Product Details
PD3B-121AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 260-310 on rat PDE3B protein. Selective for only PDE3B variant
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGI PDE; CGI-PDE B; CGIP1; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; cyclic nucleotide phosphodiesterase; phosphodiesterase 3B cGMP inhibited; phosphodiesterase 3B, cGMP-inhibited; RcGIPl
Gene Aliases: 9830102A01Rik; AI847709; cGIPDE1; HcGIP1; PDE3B
UniProt ID: (Human) Q13370, (Mouse) Q61409, (Rat) Q63085
Entrez Gene ID: (Chicken) 423064, (Human) 5140, (Mouse) 18576, (Rat) 29516
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
protein kinase B binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
drug binding
cAMP binding
phosphoprotein binding
phosphodiesterase
angiogenesis
negative regulation of cell adhesion
signal transduction
G-protein coupled receptor signaling pathway
insulin receptor signaling pathway
negative regulation of angiogenesis
negative regulation of cell adhesion mediated by integrin
regulation of angiogenesis
negative regulation of lipid catabolic process
regulation of protein kinase B signaling
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cAMP catabolic process
endocrine pancreas development
glucose homeostasis
negative regulation of insulin secretion
regulation of insulin secretion
diterpenoid metabolic process
cellular response to insulin stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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