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Fabgennix

PDE4 Polyclonal Antibody, Biotin

View all (3) PDE4 antibodies

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Product Details

PD4-BIOTIN

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate. It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4A; 3',5'-cyclic-AMP phosphodiesterase 4D; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4A; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP (cAMP)-specific phosphodiesterase; cyclic AMP specific phosphodiesterase family 4 sub-family A isoform 11; cyclic AMP specific phosphodiesterase PDE4A5A; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE2; DPDE3; dunce; PDE43; PDE46; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; phosphodiesterase 4D, cAMP-specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; testicular tissue protein Li 136; type-IVA cyclic AMP specific phosphodiesterase HPDE4A

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Gene Aliases: 9630011N22Rik; ACRDYS2; D9Ertd60e; DPDE2; DPDE3; HSPDE4D; PDE4; PDE43; PDE46; PDE4A; PDE4D; PDE4DN2; PHOSA; STRK1

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UniProt ID: (Human) P27815, (Human) Q08499, (Mouse) O89084, (Rat) P54748, (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Human) 5141, (Chicken) 769469, (Human) 5144, (Mouse) 18577, (Rat) 25638, (Rat) 24627, (Mouse) 238871

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Function(s)
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding phosphoric diester hydrolase activity hydrolase activity cAMP binding metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity calcium channel regulator activity enzyme binding receptor regulator activity beta-2 adrenergic receptor binding ion channel binding ATPase binding scaffold protein binding heterocyclic compound binding cyclic-nucleotide phosphodiesterase activity drug binding SH3 domain binding protein domain specific binding ubiquitin protein ligase binding phosphodiesterase
Process(es)
cAMP catabolic process signal transduction G-protein coupled receptor signaling pathway sensory perception of smell cellular response to xenobiotic stimulus regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cAMP/PKA signal transduction negative regulation of cAMP/PKA signal transduction regulation of heart rate positive regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of heart contraction T cell receptor signaling pathway establishment of endothelial barrier cellular response to cAMP cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of protein kinase A signaling cellular response to drug regulation of cAMP-mediated signaling metabolic process response to drug smooth muscle contraction aging memory regulation of G-protein coupled receptor protein signaling pathway regulation of receptor activity positive regulation of smooth muscle cell migration lung development neutrophil chemotaxis negative regulation of peptidyl-serine phosphorylation multicellular organism growth cellular protein complex assembly positive regulation of smooth muscle cell proliferation leukocyte migration regulation of ryanodine-sensitive calcium-release channel activity cellular response to lipopolysaccharide adrenergic receptor signaling pathway involved in positive regulation of heart rate
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