Fabgennix

PDE4B1 Polyclonal Antibody, FITC

Product Details

PD4B1-FITC

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
ELISA (ELISA)	1:10,000	-
Immunoprecipitation (IP)	1:50-1:250	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide selective only for PDE4B1 subtype variant.
Conjugate	FITC
Excitation/Emission Max	498/517 nm View spectra
Form	Liquid
Concentration	0.5-1.5 mg/mL
Purification	Affinity chromatography
Storage buffer	proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, store in dark

Target Information

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DKFZp686F2182; DPDE4; dunce-like phosphodiesterase E4; MGC126529; MGC93193; OTTHUMP00000046896; PDE32; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); RP5-876C12.1

Gene Aliases: DPDE4; dunce; PDE4/IVb; PDE4B; Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDEIVB; R74983

UniProt ID: (Human) Q07343, (Rat) P14646

Entrez Gene ID: (Human) 5142, (Rat) 24626, (Mouse) 18578

Molecular Function: phosphodiesterase