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Proteintech
PDE4D Polyclonal Antibody
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Product Details
12918-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDE4D Fusion Protein Ag3588 (170-518 aa encoded by BC036319)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV FNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL VHPDAQDILD TLEDNREWYQ STIPQSPSPA PDDPEEGRQG QTEKFQFELT LEEDGESDTE KDSGSQVEED TSCSDSKTLC TQDSESTEIP LDEQVEEEAV GEEEESQPEA CVIDDRSPDT (170-518 aa encoded by BC036319)
Target Information
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136
Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1
UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
drug binding
enzyme binding
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
metal ion binding
ATPase binding
scaffold protein binding
cyclic-nucleotide phosphodiesterase activity
SH3 domain binding
protein domain specific binding
ubiquitin protein ligase binding
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
neutrophil chemotaxis
regulation of cAMP metabolic process
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
negative regulation of heart contraction
T cell receptor signaling pathway
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
memory
regulation of G-protein coupled receptor protein signaling pathway
regulation of protein kinase A signaling
positive regulation of smooth muscle cell migration
lung development
cellular protein complex assembly
positive regulation of smooth muscle cell proliferation
leukocyte migration
cellular response to cAMP
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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