This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
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Protein Aliases: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; dunce-like phosphodiesterase E3; FLJ97311; HGNC:8783; HSPDE4D; PDE43; PDE4D; PDE4DN2; phosphodiesterase 4D; phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3); phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); STRK1; testicular tissue protein Li 136
Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1