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Fabgennix

PDE4D3 Polyclonal Antibody

View all (2) PDE4D3 antibodies

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Additional Information:

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Product Details

PD4D3-431AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Chicken, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant gene.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PDE4D3 (Phosphodiesterase 4D, cAMP-specific, isoform 3) is an enzyme encoded by the PDE4D gene, which is located on chromosome 5. PDE4D3 belongs to the PDE4 family, which plays a crucial role in hydrolyzing cyclic AMP (cAMP), thereby regulating intracellular levels of this important signaling molecule. PDE4D3 is integral in modulating cAMP signaling pathways, impacting processes such as cardiac function and inflammation. This isoform of phosphodiesterase has been found to interact within a large protein complex, including Epac1, PKA, and ERK5, which is anchored by mAKAP. Phosphorylation by ERK decreases PDE4D3 activity, leading to local cAMP accumulation and increased activation of cAMP-dependent pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D3; PDE4D6; PDE4D7; phosphodiesterase 4D, cAMP-specific; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); splice variant PDE4D4; unnamed protein product

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Gene Aliases: 9630011N22Rik; DPDE3; PDE3/IVd

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UniProt ID: (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Chicken) 769469, (Rat) 24627, (Mouse) 238871

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Function(s)
cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity calcium channel regulator activity protein binding phosphoric diester hydrolase activity enzyme binding receptor regulator activity cAMP binding beta-2 adrenergic receptor binding ion channel binding 3',5'-cyclic-GMP phosphodiesterase activity ATPase binding scaffold protein binding heterocyclic compound binding phosphodiesterase
Process(es)
ovulation from ovarian follicle positive regulation of protein phosphorylation regulation of heart rate cAMP catabolic process smooth muscle contraction signal transduction memory positive regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of smooth muscle cell migration positive regulation of cell-cell adhesion lung development neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production multicellular organism growth negative regulation of heart contraction positive regulation of smooth muscle cell proliferation T cell receptor signaling pathway leukocyte migration establishment of endothelial barrier protein-containing complex assembly cellular response to lipopolysaccharide cellular response to cAMP cellular response to follicle-stimulating hormone stimulus cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway cAMP/PKA signal transduction regulation of cAMP/PKA signal transduction negative regulation of cAMP/PKA signal transduction regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of G-protein coupled receptor protein signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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