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PDE5 Antibody (PA5-79796) in WB
Western blot analysis of PDE5 in rat lung extract (lane 1) and PANC-1 whole cell lysate(lane 2). Sample was incubated with PDE5 polyclonal antibody (Product # PA5-79796) at a dilution of 0.5 µg/mL. Signal development was performed using a chemiluminescence (ECL) kit.
Product Details
PA5-79796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human PDE5A (20-63aa QKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVH).
Conjugate
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
RRID
AB_2746911
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP] are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messenger which play important role in a variety of signal transduction process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5; phosphodiesterase type 5
Gene Aliases: CGB-PDE; CN5A; PDE5; PDE5A; PDE5A2
UniProt ID: (Human) O76074, (Rat) O54735
Entrez Gene ID: (Human) 8654, (Rat) 171115
Molecular Function:
phosphodiesterase
signal transduction
positive regulation of cardiac muscle hypertrophy
regulation of cGMP metabolic process
negative regulation of T cell proliferation
positive regulation of MAP kinase activity
cGMP catabolic process
negative regulation of cardiac muscle contraction
relaxation of cardiac muscle
positive regulation of oocyte development
response to hypoxia
regulation of the force of heart contraction
positive regulation of chronic inflammatory response
nervous system development
short-term memory
response to lipopolysaccharide
response to testosterone
vasodilation
positive regulation of apoptotic process
positive regulation of vasoconstriction
cGMP metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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