Invitrogen

PDE5 Polyclonal Antibody

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PDE5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of PDE5 on paraffin-embedded human thyroid cancer tissue. Sample was incubated with PDE5 polyclonal antibody (Product# PA5-79796) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) method.

PDE5 Antibody in Western Blot (WB) — Western blot analysis of PDE5 in rat lung extract (lane 1) and PANC-1 whole cell lysate(lane 2). Sample was incubated with PDE5 polyclonal antibody (Product # PA5-79796) at a dilution of 0.5 µg/mL. Signal development was performed using a chemiluminescence (ECL) kit.

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL

Western Blot (WB)

0.1-0.5 µg/mL

Product Specifications

Species Reactivity

Human, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human PDE5A.

Conjugate

Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

RRID

AB_2746911

Product Specific Information

The synthetic peptide sequence is 20-63aa, QKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVH

Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.

Target Information

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP] are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messenger which play important role in a variety of signal transduction process.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-cyclic phosphodiesterase; CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3'; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5; phosphodiesterase type 5

Gene Aliases: CGB-PDE; CN5A; PDE5; PDE5A; PDE5A2

UniProt ID: (Human) O76074, (Rat) O54735

Entrez Gene ID: (Human) 8654, (Rat) 171115

Molecular Function: hydrolase phosphodiesterase