Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
22624-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Rabbit |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PDE5A Fusion Protein Ag18779 (321-482 aa encoded by BC126233) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.23 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: ETSLLENKR NQVLLDLASL IFEEQQSLEV ILKKIAATII SFMQVQKCTI FIVDEDCSDS FSSVFHMECE ELEKSSDTLT REHDANKINY MYAQYVKNTM EPLNIPDVSK DKRFPWTTEN TGNVNQQCIR SLLCTPIKNG KKNKVIGVCQ LVNKMEENTG KVK (321-482 aa encoded by BC126233)
Target Information
The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP] are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messenger which play important role in a variety of signal transduction process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-binding/cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5
Gene Aliases: CGB-PDE; Cgbpde; CN5A; Cn5n; PDE5; PDE5A; Pde5a1
UniProt ID: (Human) O76074, (Mouse) Q8CG03
Entrez Gene ID: (Human) 8654, (Mouse) 242202
Molecular Function:
phosphodiesterase
signal transduction
positive regulation of cardiac muscle hypertrophy
regulation of cGMP metabolic process
negative regulation of T cell proliferation
positive regulation of MAP kinase activity
cGMP catabolic process
negative regulation of cardiac muscle contraction
relaxation of cardiac muscle
positive regulation of oocyte development
regulation of the force of heart contraction
positive regulation of chronic inflammatory response
short-term memory
metabolic process
positive regulation of apoptotic process
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of vasoconstriction
cGMP metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support