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Product Details
PD5A-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide common to all PDE5A variants taken within amino acid region 825-875 on human PDE5A protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP] are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messenger which play important role in a variety of signal transduction process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-binding/cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; phosphodiesterase 5; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5; phosphodiesterase type 5
Gene Aliases: CGB-PDE; Cgbpde; CN5A; Cn5n; PDE5; PDE5A; Pde5a1; PDE5A2
UniProt ID: (Human) O76074, (Rat) O54735, (Mouse) Q8CG03
Entrez Gene ID: (Human) 8654, (Chicken) 422677, (Rat) 171115, (Mouse) 242202
signal transduction
positive regulation of cardiac muscle hypertrophy
regulation of cGMP metabolic process
negative regulation of T cell proliferation
positive regulation of MAP kinase activity
cGMP catabolic process
negative regulation of cardiac muscle contraction
relaxation of cardiac muscle
positive regulation of oocyte development
response to hypoxia
regulation of the force of heart contraction
positive regulation of chronic inflammatory response
nervous system development
short-term memory
response to lipopolysaccharide
response to testosterone
vasodilation
positive regulation of apoptotic process
positive regulation of vasoconstriction
cGMP metabolic process
metabolic process
positive regulation of G-protein coupled receptor protein signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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