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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Turkey, Chicken (94%); Platypus (89%).^M
^M
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 7B; cAMP-specific phosphodiesterase 7B; high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase; MGC88256; rolipram-insensitive phosphodiesterase type 7; RP11-472E5.2
Gene Aliases: bA472E5.1; PDE7B
UniProt ID: (Human) Q9NP56
Entrez Gene ID: (Human) 27115
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