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Product Details
13956-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2400 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Miscellaneous PubMed (Misc) |
- | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Not Applicable |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PDE8A Fusion Protein Ag5069 (530-829 aa encoded by BC060762) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.42 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: FLHCSESTL RSWLQIIEAN YHSSNPYHNS THSADVLHAT AYFLSKERIK ETLDPIDEVA ALIAATIHDV DHPGRTNSFL CNAGSELAIL YNDTAVLESH HAALAFQLTT GDDKCNIFKN MERNDYRTLR QGIIDMVLAT EMTKHFEHVN KFVNSINKPL ATLEENGETD KNQEVINTML RTPENRTLIK RMLIKCADVS NPCRPLQYCI EWAARISEEY FSQTDEEKQQ GLPVVMPVFD RNTCSIPKSQ ISFIDYFITD MFDAWDAFVD LPDLMQHLDN NFKYWKGLDE MKLRNLRPPP E (530-829 aa encoded by BC060762)
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; MmPDE8
Gene Aliases: AI551852; HsT19550; Pde8; PDE8A; RNPDE8A
UniProt ID: (Human) O60658, (Mouse) O88502
Entrez Gene ID: (Human) 5151, (Mouse) 18584, (Rat) 308776
Molecular Function:
phosphodiesterase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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