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Proteintech
PDE8A Polyclonal Antibody
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Product Details
13956-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDE8A Fusion Protein Ag5069 (530-829 aa encoded by BC060762)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Amount
63 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FLHCSESTL RSWLQIIEAN YHSSNPYHNS THSADVLHAT AYFLSKERIK ETLDPIDEVA ALIAATIHDV DHPGRTNSFL CNAGSELAIL YNDTAVLESH HAALAFQLTT GDDKCNIFKN MERNDYRTLR QGIIDMVLAT EMTKHFEHVN KFVNSINKPL ATLEENGETD KNQEVINTML RTPENRTLIK RMLIKCADVS NPCRPLQYCI EWAARISEEY FSQTDEEKQQ GLPVVMPVFD RNTCSIPKSQ ISFIDYFITD MFDAWDAFVD LPDLMQHLDN NFKYWKGLDE MKLRNLRPPP E (530-829 aa encoded by BC060762)
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HSPDE8A1; HSPDE8A2; HSPDE8A3; HSPDE8A4; HSPDE8A5; MmPDE8; PDE8A; unnamed protein product
Gene Aliases: AI551852; HsT19550; Pde8; PDE8A; RNPDE8A
UniProt ID: (Human) O60658, (Mouse) O88502
Entrez Gene ID: (Human) 5151, (Mouse) 18584, (Rat) 308776
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
kinase binding
protein kinase activator activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
signal transducer activity
molecular_function
phosphodiesterase
cAMP catabolic process
regulation of transcription, DNA-templated
signal transduction
positive regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
negative regulation of cAMP/PKA signal transduction
phosphorelay signal transduction system
biological_process
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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