PA1-31144 detects PDE8B from rat, human, mouse samples.
PA1-31144 has been successfully used in Western blot and imunnoprecipitation applications.
The PA1-31144 immunogen is: Synthetic peptide (Human).
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
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Protein Aliases: 3',5' cyclic nucleotide phosphodiesterase 8B; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; Cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B; PPNAD3
Gene Aliases: ADSD; B230331L10Rik; C030047E14Rik; PDE8B; PIG22; PPNAD3; RNPDE8B
UniProt ID: (Human) O95263