Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-27394 detects PDGF beta from human, mouse, rat, bovine, feline, canine, golden hamster, and ovine samples.
PA1-27394 has been successfully used in immunohistochemistry (paraffin) procedures. Perform heat mediated antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol. A suggested positive control for this product is angiosarcoma.
The PA1-27394 immunogen is a synthetic peptide corresponding to residues T(101) E V F E I S R R L I D R T N A(116) of human PDGF beta.
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Becaplermin; c-sis; pdgf protein; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF-B; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; platelet-derived growth factor B; Platelet-derived growth factor B chain; platelet-derived growth factor B subunit; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); Proto-oncogene c-Sis; v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
Gene Aliases: PDGF2; PDGFB; SIS
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