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      Invitrogen

      PDGF-D Polyclonal Antibody

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      Catalog #:40-2100

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      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) 3-5 µg/10^6 cells
      Immunohistochemistry (Paraffin) (IHC (P)) 1:50
      Western Blot (WB) Assay Dependent
      PUBLISHED APPLICATIONS
      Immunohistochemistry (Paraffin) (IHC (P)) See 1 publications below
      Tested Species reactivity Human, Mouse, Rat
      Published species reactivity Not Applicable
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide derived from the C-terminal region of the human PDGF-D
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.25 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS, pH 7.4
      Contains 0.1% sodium azide
      Storage conditions -20°C
      RRID AB_2533455

      Background/Target Information

      The platelet-derived growth factor (PDGF) family consists of four members; PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-a and PDGFR-b, and PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and by stimulation of tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines including those derived from ovarian, renal and lung cancers, as well as from astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (1)

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      Bioinformatics

      Protein Aliases: Iris-expressed growth factor; PDGF-D; Platelet-derived growth factor D; platelet-derived growth factor, D polypeptide; SCDGF-B; spinal cord derived growth factor B; Spinal cord-derived growth factor B; spinal cord-derived growth factor-B; Spinal-cord derived growth factor-B; spinal-cord derived growth factor-B protein

      Gene Aliases: 1110003I09Rik; IEGF; MSTP036; PDGFD; rSCDGF-B; SCDGF-B; SCDGFB; UNQ1899/PRO4345

      UniProt ID: (Human) Q9GZP0, (Mouse) Q925I7, (Rat) Q9EQT1

      Entrez Gene ID: (Human) 80310, (Mouse) 71785, (Rat) 66018

      Molecular Function: growth factor signaling molecule

      Suggested Secondary Antibodies

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