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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PDGFAA/PDGFBB Antibodies

          Bioss

          PDGFAA + PDGFBB Polyclonal Antibody

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          Cite PDGFAA + PDGFBB Polyclonal Antibody

          Product Details

          BS-12157R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human PDGFAA + PDGFBB.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: becaplermin; c-sis; PDGF A-chain; pdgf protein; PDGF subunit A; PDGF subunit B; PDGF, B chain; PDGF-1; PDGF-2; platelet derived growth factor, alpha; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; Platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit A; Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); Proto-oncogene c-Sis

          View more View less

          Gene Aliases: c-sis; IBGC5; PDGF-2; PDGF-A; PDGF-B; PDGF1; PDGF2; PDGFA; PDGFACP; PDGFB; Rpa1; SIS; SSV

          View more View less

          UniProt ID: (Human) P04085, (Human) P01127, (Rat) P28576, (Mouse) P20033, (Mouse) P31240, (Rat) Q05028

          View more View less

          Entrez Gene ID: (Human) 5154, (Human) 5155, (Rat) 25266, (Mouse) 18590, (Mouse) 18591, (Rat) 24628

          View more View less

          Function(s)
          Ras guanyl-nucleotide exchange factor activity platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity platelet-derived growth factor binding superoxide-generating NADPH oxidase activator activity chemoattractant activity identical protein binding receptor binding growth factor
          Process(es)
          MAPK cascade angiogenesis response to hypoxia cell activation hair follicle development positive regulation of mesenchymal cell proliferation platelet degranulation transforming growth factor beta receptor signaling pathway cell-cell signaling positive regulation of cell proliferation response to wounding organ morphogenesis response to inorganic substance negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling regulation of smooth muscle cell migration cell projection assembly actin cytoskeleton organization extracellular matrix organization positive regulation of cell migration positive regulation of protein autophosphorylation response to estradiol response to retinoic acid regulation of actin cytoskeleton organization positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway wound healing response to drug positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity skin development positive regulation of DNA replication phosphatidylinositol phosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation lung alveolus development inner ear development regulation of peptidyl-tyrosine phosphorylation negative chemotaxis positive regulation of cell division positive regulation of protein kinase B signaling regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling positive regulation of ERK1 and ERK2 cascade regulation of glomerular mesangial cell proliferation embryonic lung development regulation of DNA biosynthetic process embryonic placenta development positive regulation of endothelial cell proliferation monocyte chemotaxis positive regulation of glomerular filtration DNA replication protein phosphorylation heart development positive regulation of gene expression negative regulation of gene expression positive regulation of smooth muscle cell migration cell growth peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation hemopoiesis negative regulation of protein binding activation of protein kinase activity activation of protein kinase B activity response to insulin paracrine signaling positive regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of chemotaxis cell chemotaxis positive regulation of protein tyrosine kinase activity protein kinase C signaling cellular response to growth factor stimulus cellular response to mycophenolic acid positive regulation of glomerular mesangial cell proliferation metanephric glomerular mesangial cell development reactive oxygen species metabolic process positive regulation of calcium ion import positive regulation of hyaluronan biosynthetic process negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular smooth muscle cell dedifferentiation positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process positive regulation of metanephric mesenchymal cell migration blood coagulation response to organic substance digestive tract development multicellular organism development bone development substrate-dependent cell migration synapse assembly neuron remodeling glial cell development negative regulation of cell migration positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway eye photoreceptor cell development positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of vasoconstriction negative regulation of vasodilation positive regulation of mitotic cell cycle, embryonic blood vessel morphogenesis retina development in camera-type eye branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis cardiac vascular smooth muscle cell differentiation retina vasculature development in camera-type eye metanephric glomerular mesangial cell proliferation involved in metanephros development response to organic cyclic compound regulation of cell proliferation metanephric glomerular endothelium development
          It has to be done as per old AB suggested Products section.
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