PA5-16571 targets PDGFR alpha in IHC applications and shows reactivity with mouse, Rat, and Human samples.
The PA5-16571 immunogen is a synthetic peptide derived from the C-terminus of the precursor form of human PDGFR, alpha.
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta; coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha; and beta;.
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Protein Aliases: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; PDGF A-chain; PDGF alpha chain; PDGF-R-alpha; PDGFR-2; pdgfr-a; PDGFR-alpha; PDGFRA/BCR fusion; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor subunit A; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Gene Aliases: AI115593; APDGFR; CD140A; GAS9; PDGFACE; PDGFR-2; PDGFR2; PDGFRA; RHEPDGFRA