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Invitrogen

PDGFRA Polyclonal Antibody

View all (87) PDGFRA (CD140a) antibodies

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PDGFRA Polyclonal Antibody

Product Details

PA5-17623

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Flow Cytometry (Flow)

1:200
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues near the carboxy-terminal sequence of human PDGF receptor a
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

140 µg/mL

Amount

14 µg

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980428

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF alpha chain; PDGF Receptor alpha; PDGF subunit A; PDGF-1; PDGF-R-alpha; PDGFR-2; pdgfr-a; PDGFR-alpha; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; unnamed protein product

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Gene Aliases: AI115593; CD140A; PDGFR-2; PDGFR2; PDGFRA; RHEPDGFRA

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UniProt ID: (Human) P16234, (Mouse) P26618

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Entrez Gene ID: (Human) 5156, (Mouse) 18595

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor alpha-receptor activity vascular endothelial growth factor-activated receptor activity platelet-derived growth factor receptor binding protein binding ATP binding kinase activity transferase activity vascular endothelial growth factor binding protein homodimerization activity macromolecular complex binding platelet-derived growth factor binding phospholipase C activator activity transferase activity, transferring phosphorus-containing groups protein complex binding phosphatidylinositol 3-kinase binding transmembrane signal receptor
Process(es)
luteinization in utero embryonic development cell activation hematopoietic progenitor cell differentiation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway estrogen metabolic process positive regulation of cell proliferation female gonad development anatomical structure morphogenesis organ morphogenesis negative regulation of platelet activation cell migration peptidyl-tyrosine phosphorylation signal transduction involved in regulation of gene expression extracellular matrix organization lung development adrenal gland development positive regulation of cell migration male genitalia development regulation of actin cytoskeleton organization Leydig cell differentiation cellular response to reactive oxygen species platelet-derived growth factor receptor-alpha signaling pathway positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing odontogenesis of dentin-containing tooth protein autophosphorylation platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis positive regulation of calcium-mediated signaling white fat cell differentiation positive regulation of chemotaxis positive regulation of protein kinase B signaling cardiac myofibril assembly palate development face morphogenesis cell chemotaxis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to amino acid stimulus metanephric glomerular capillary formation regulation of mesenchymal stem cell differentiation protein phosphorylation positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of phospholipase C activity phosphorylation cellular response to platelet-derived growth factor stimulus positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication phosphatidylinositol-mediated signaling regulation of chemotaxis
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