PDGFRL bears significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in the PDGFRL gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests PDGFRL may function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PDGF receptor beta-like tumor suppressor; PDGFR like protein; PDGFR-like protein; PDGFRL; PDGRL; Platelet-derived growth factor receptor-like protein; platelet-derived growth factor-beta-like tumor suppressor; PRLTS
Gene Aliases: 1110039P19Rik; AV013190; PDGFRL; PDGRL; PRLTS