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Product Details
15545-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDIR Fusion Protein Ag7901 (1-262 aa encoded by BC001625)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MARAGPAWL LLAIWVVLPS WLSSAKVSSL IERISDPKDL KKLLRTRNNV LVLYSKSEVA AENHLRLLST VAQAVKGQGT ICWVDCGDAE SRKLCKKMKV DLSPKDKKVE LFHYQDGAFH TEYNRAVTFK SIVAFLKDPK GPPLWEEDPG AKDVVHLDSE KDFRRLLKKE EKPLLIMFYA PWCSMCKRMM PHFQKAATQL RGHAVLAGMN VYSSEFENIK EEYSVRGFPT ICYFEKGRFL FQYDNYGSTA EDIVEWLKKV WPL (1-262 aa encoded by BC001625)
Target Information
PDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal 'Lys-Glu-Glu-Leu' at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: protein disulfide isomerase A5; protein disulfide isomerase family A, member 5; protein disulfide isomerase-associated 5; Protein disulfide isomerase-related protein; Protein disulfide-isomerase A5
Gene Aliases: 2700053F16Rik; AU015525; PDIA5; PDIR
UniProt ID: (Human) Q14554, (Mouse) Q921X9, (Rat) Q5I0H9
Entrez Gene ID: (Human) 10954, (Mouse) 72599, (Rat) 360722
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