Recommended positive controls: A549, HepG2, HCT116.
Predicted reactivity: Mouse (90%), Rat (91%), Sheep (91%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal 'Lys-Glu-Glu-Leu' at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: protein disulfide isomerase family A, member 5; protein disulfide isomerase-associated 5; Protein disulfide isomerase-related protein; Protein disulfide-isomerase A5
Gene Aliases: 2700053F16Rik; AU015525; PDIA5; PDIR
Molecular Function: chaperone