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Invitrogen
PDX1 Polyclonal Antibody
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FIGURE: 1 / 1
PDX1 Antibody (PA5-91915) in WB
Western blot analysis of PDX1 in extracts of mouse intestine. Samples were incubated with PDX1 Polyclonal antibody (Product # PA5-91915) using a dilution of 1:400, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-91915
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1 (P52945)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
44 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse intestine; Cellular Location: Cytoplasm, Nucleus, cytosol
Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLDBP; E3BP; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; IPF-1; Islet/duodenum homeobox 1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; PDHX; Somatostatin-transactivating factor 1; STF-1
Gene Aliases: IDX-1; IPF-1; Ipf1; Mody4; pdx-1; Pdx1; STF-1
UniProt ID: (Mouse) P52946
Entrez Gene ID: (Mouse) 18609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
protein complex binding
sequence-specific DNA binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
nitric oxide mediated signal transduction
multicellular organism development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to glucose
regulation of gene expression
positive regulation of cell death
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
positive regulation of insulin secretion
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
glucose homeostasis
positive regulation of DNA binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
detection of glucose
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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