Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Rabbit (86%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CFTR-associated protein of 70 kDa; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-C; NaPi-Cap1; NHERF-3; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; PDZK 1; PDZK-1; Sodium-hydrogen exchanger regulatory factor 3
Gene Aliases: CAP70; CLAMP; NHERF-3; NHERF3; PDZD1; PDZK1
UniProt ID: (Human) Q5T2W1
Entrez Gene ID: (Human) 5174