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Product Details
PA5-117726
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000-1:5,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404aa) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
3 mg/mL |
Purification |
Protein G |
Storage buffer |
10mM PBS, pH 7.4, with 50% glycerol |
Contains |
0.03% ProClin 300 |
Storage conditions |
-20°C or -80°C if preferred |
RRID |
AB_2902355 |
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase PDZRN3; Ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; PDZ domain containing RING finger 3A; PDZ domain-containing RING finger protein 3; Protein SEMACAP3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3; semaphorin cytoplasmic domain-associated protein 3A
Gene Aliases: 1110020C07Rik; AI429718; AL023082; KIAA1095; LNX3; PDZRN3; SEMACAP3; SEMCAP3
UniProt ID: (Human) Q9UPQ7, (Mouse) Q91Z03
Entrez Gene ID: (Human) 23024, (Mouse) 55983
Molecular Function:
scaffold/adaptor protein
ubiquitin-protein transferase activity
zinc ion binding
ligase activity
ubiquitin protein ligase activity
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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