Search

  • Contáctenos
  • Orden Rápida

Proteintech

CD29 Recombinant Mouse Monoclonal Antibody (TS2/16), PE

View all (116) Integrin beta 1 (CD29) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PE-65601

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

TS2/16

Immunogen

fusion protein

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

5 µL/Test

Purification

Protein A

Storage buffer

PBS with 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Wet ice

Target Information

CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; Integrin beta-1; integrin beta-1 subunit (cytoplasmic domain); Integrin beta1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; unnamed protein product; very late activation protein, beta polypeptide; VLA-4 subunit beta

View more View less

Gene Aliases: CD29; FNRB; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB

View more View less

UniProt ID: (Human) P05556

View more View less

Entrez Gene ID: (Human) 3688

View more View less

Function(s)
magnesium ion binding virus receptor activity fibronectin binding protease binding actin binding integrin binding calcium ion binding protein binding coreceptor activity protein kinase binding C-X3-C chemokine binding signaling receptor activity laminin binding macromolecular complex binding cadherin binding metal ion binding protein heterodimerization activity cell adhesion molecule binding collagen binding involved in cell-matrix adhesion integrin binding involved in cell-matrix adhesion protein tyrosine kinase binding
Process(es)
G1/S transition of mitotic cell cycle establishment of mitotic spindle orientation angiogenesis in utero embryonic development cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation phagocytosis cellular defense response cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway neuroblast proliferation muscle organ development myoblast fusion cell proliferation germ cell migration visual learning regulation of collagen catabolic process positive regulation of fibroblast migration response to muscle activity cell migration formation of radial glial scaffolds central nervous system neuron differentiation CD40 signaling pathway cell projection organization lamellipodium assembly B cell differentiation extracellular matrix organization positive regulation of cell migration neuron projection development cell-substrate adhesion receptor internalization cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion negative regulation of Rho protein signal transduction wound healing, spreading of epidermal cells maintenance of blood-brain barrier positive regulation of apoptotic process stress fiber assembly positive regulation of GTPase activity sarcomere organization myoblast differentiation negative regulation of neuron differentiation positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of vasoconstriction viral entry into host cell mesodermal cell differentiation myoblast fate specification axon extension dendrite morphogenesis regulation of developmental process modulation of synaptic transmission leukocyte tethering or rolling regulation of cell cycle positive regulation of protein kinase B signaling positive regulation of glutamate uptake involved in transmission of nerve impulse cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation cardiac cell fate specification regulation of biological quality cellular response to low-density lipoprotein particle stimulus basement membrane organization positive regulation of wound healing cell-cell adhesion regulation of spontaneous synaptic transmission reactive gliosis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of protein localization to plasma membrane regulation of synapse pruning negative regulation of anoikis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support