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Bioss
PEDF Polyclonal Antibody
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Product Details
BS-20784R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PEDF, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2 antiplasmin; Caspin; Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PIG 35; pigment epithelium derived factor; Pigment epithelium-derived factor; SDF-3; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; Serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin-F1; SERPINF 1; sserpin family F member 1; stromal cell derived factor 3; Stromal cell-derived factor 3; testis tissue sperm-binding protein Li 70n
Gene Aliases: AI195227; EPC-1; OI12; OI6; PEDF; Pedfl; PIG35; Sdf3; SERPINF1
UniProt ID: (Human) P36955, (Mouse) P97298
Entrez Gene ID: (Human) 5176, (Mouse) 20317
kidney development
multicellular organism development
aging
short-term memory
cell proliferation
response to acidic pH
negative regulation of endothelial cell migration
negative regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of neuron projection development
negative regulation of angiogenesis
ovulation cycle
response to arsenic-containing substance
negative regulation of inflammatory response
positive regulation of neurogenesis
retina development in camera-type eye
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to cobalt ion
cellular response to retinoic acid
cellular response to glucose stimulus
cellular response to dexamethasone stimulus
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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