The antibody detects endogenous levels of total PEG3 protein.
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed. Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: KIAA0287; Kruppel-type zinc finger protein; Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24; ZSCAN24
Gene Aliases: KIAA0287; PEG3; PW1; ZKSCAN22; ZNF904; ZSCAN24
UniProt ID: (Human) Q9GZU2
Entrez Gene ID: (Human) 5178