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Proteintech
PELI2 Polyclonal Antibody
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Product Details
16097-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PELI2 Fusion Protein Ag8940 (281-420 aa encoded by BC009476)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RPQCPVGLN TLAFPSINRK EVVEEKQPWA YLSCGHVHGY HNWGHRSDTE ANERECPMCR TVGPYVPLWL GCEAGFYVDA GPPTHAFTPC GHVCSEKSAK YWSQIPLPHG THAFHAACPF CATQLVGEQN CIKLIFQGPI D (281-420 aa encoded by BC009476)
Target Information
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase pellino homolog 2; pellino 2; pellino homolog 2; Pellino-2; protein pellino homolog 2; RING-type E3 ubiquitin transferase pellino homolog 2; unnamed protein product
Gene Aliases: AW047589; BB129927; PELI2; RGD1565884
UniProt ID: (Human) Q9HAT8, (Mouse) Q8BST6
Entrez Gene ID: (Human) 57161, (Rat) 305835, (Mouse) 93834
protein binding
transferase activity
ubiquitin-ubiquitin ligase activity
ubiquitin protein ligase activity
molecular_function
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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