Proteintech

PELO Polyclonal Antibody

PELO Antibody in Immunocytochemistry (ICC/IF)

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PELO Antibody (10582-1-AP) in ICC/IF

IF result of 10582-1-AP (PELO antibody) in U2OS cell by Dr. Nancy Kedersha. (cytoplasm and nucleus; Green).

PELO Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PELO Antibody in Immunoprecipitation (IP)

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Product Details

10582-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PELO Fusion Protein Ag0873 (62-384 aa encoded by BC005889)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHIC LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHIHFD VVKCILVASP GFVREQFCDY MFQQAVKTDN KLLLENRSKF LQVHASSGHK YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH VSGEQLSQLT GVAAILRFPV PELSDQEGDS SSEE (62-384 aa encoded by BC005889)

Target Information

PELO encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.

Immunity

Wu X,Yang ZH,Wu J,Han J

Tue May 09 00:00:00 UTC 2023

Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress.

Molecular cell

Stoneley M,Harvey RF,Mulroney TE,Mordue R,Jukes-Jones R,Cain K,Lilley KS,Sawarkar R,Willis AE

Thu Apr 21 00:00:00 UTC 2022

Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.

eLife

Terrey M,Adamson SI,Chuang JH,Ackerman SL

Mon Apr 26 00:00:00 UTC 2021

A role for the ribosome-associated complex in activation of the IRE1 branch of UPR.

Cell reports

Wu IH,Yoon JS,Yang Q,Liu Y,Skach W,Thomas P

Tue Jun 08 00:00:00 UTC 2021

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

PLoS genetics

O'Connell AE,Gerashchenko MV,O'Donohue MF,Rosen SM,Huntzinger E,Gleeson D,Galli A,Ryder E,Cao S,Murphy Q,Kazerounian S,Morton SU,Schmitz-Abe K,Gladyshev VN,Gleizes PE,Séraphin B,Agrawal PB

Fri Feb 01 00:00:00 UTC 2019

XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.

Nucleic acids research

Hou S,Qu D,Li Y,Zhu B,Liang D,Wei X,Tang W,Zhang Q,Hao J,Guo W,Wang W,Zhao S,Wang Q,Azam S,Khan M,Zhao H,Zhang L,Lei H

Thu Sep 05 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: hPelota; Protein Dom34 homolog; Protein pelota homolog

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Gene Aliases: AA409897; AI852218; CGI-17; PELO; PRO1770

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UniProt ID: (Human) Q9BRX2, (Mouse) Q80X73, (Rat) Q5XIP1

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Entrez Gene ID: (Human) 53918, (Mouse) 105083, (Rat) 294754

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Function(s)

endonuclease activity protein binding metal ion binding nuclease activity hydrolase activity phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity translation release factor

Process(es)

cell cycle cell proliferation chromosome organization cell division nuclear-transcribed mRNA catabolic process, non-stop decay nuclear-transcribed mRNA catabolic process, no-go decay RNA surveillance nucleic acid phosphodiester bond hydrolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PELO Polyclonal Antibody

PELO Antibody (10582-1-AP) in ICC/IF

Product Details

10582-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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