Peptide sequence: GWAIMHASPT GLLLTVLVAL TYIVALLYEE PFTAEIYRQK ASGSHKRS
Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 83%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 86%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 82%
This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.
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Protein Aliases: MGC2483; PEAMT; PEMT2; Phosphatidylethanolamine N-methyltransferase; Phospholipid methyltransferase; PLMT
Gene Aliases: PEAMT; PEMPT; PEMT; PEMT2; PHOMETH; PNMT