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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.5-1 µg/mL | - |
Immunohistochemistry (IHC) |
2.5 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A 13 amino acid peptide from near the amino terminus of human PEN2. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11155987 |
A suggested positive control is A-20 cell lysate.
PA5-20302 can be used with blocking peptide PEP-0427.
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; Liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; Presenilin enhancer protein 2
Gene Aliases: 1700023M09Rik; MDS033; MSTP064; PEN-2; PEN2; PSENEN; RGD1312037
UniProt ID: (Human) Q9NZ42, (Mouse) Q9CQR7, (Rat) Q6QI68
Entrez Gene ID: (Human) 55851, (Mouse) 66340, (Rat) 292788
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