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Invitrogen
Human PAR4 (aa 324-342) Synthetic Peptide
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Product Details
PEP-060
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-060 is a 19 amino acid synthetic peptide whose sequence corresponds to residues 324-342 of human Par-4 conjugated to KLH. The sequence of this peptide is (amino to carboxy terminus): (C)-E324-Q-L-K-Q-E-N-K-T-L-L-K-V-V-G-Q-L-T-R342
This peptide conjugate may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and human Par-4 , catalog # PA1-755. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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