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Invitrogen
Human BACE1 (aa 485-501) Synthetic Peptide
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Product Details
PEP-093
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-093 is a 16 amino acid synthetic peptide whose sequence corresponds to residues 485-501 of human beta-secretase conjugated to KLH. The sequence of this peptide is (amino to carboxy terminus): C485-L-R-Q-Q-H-D-D-F-A-D-D-I-S-L-L-K501
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human beta-secretase, catalog # PA1-757. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE-1B; BACE-1C; BACE-1D; BACE-I-432; BACEdelta7; Beta secretase; Beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP processing enzyme; beta-site APP-cleaving enzyme; Memapsin; Memapsin-2; Memapsin2; membrane type aspartyl protease; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; unnamed protein product
Gene Aliases: ASP2; BACE; BACE1; HSPC104; KIAA1149
UniProt ID: (Human) P56817
Entrez Gene ID: (Human) 23621
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