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Invitrogen
Human Nicastrin (aa 688-708) Synthetic Peptide
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Product Details
PEP-131
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-131 is a 21 amino acid synthetic peptide whose sequences are derived from human nicastrin protein. The sequence of this peptide is (amino to carboxy terminus): C (688)-I-N-A-K-A-D-V-L-F-I-A-P-R-E-P-G-A-V-S-Y (708)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human nicastrin, catalog # PA1-758. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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