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Invitrogen
Mouse Caveolin 2 (aa 14-25) Synthetic Peptide
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Product Details
PEP-180
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-180 is a 12 amino acid synthetic peptide whose sequence is derived from mouse caveoiln-2 protein with tyrosine 19 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: M (14)-A-D-D-A- (pY)-S-H-H-S-G-C (25)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse phospho-caveolin-2, catalog # PA1-060. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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