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Invitrogen
Human PNR (aa 392-410) Synthetic Peptide
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Product Details
PEP-237
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-237 is a 19 amino acid synthetic peptide corresponding to amino acid residues 392-410 from human PNR. The sequence of this peptide is (amino to carboxy terminus): R K T I G N T P M E K L L C D M F K N.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-809. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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