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Invitrogen
PER2 Polyclonal Antibody
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FIGURE: 1 / 1
PER2 Antibody (PA5-110098) in WB
Western blot analysis of PER2 in extracts of 293T cells. Samples were incubated with PER2 Polyclonal antibody (Product # PA5-110098) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-110098
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 390-565 of human PER2 (NP_0737281)
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Amount
73 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GQPFDYSPIR FRARNGEYIT LDTSWSSFIN PWSRKISFII GRHKVRVGPL NEDVFAAHPC TEEKALHPSI QELTEQIHRL LLQPVPHSGS SGYGSLGSNG SHEHLMSQTS SSDSNGHEDS RRRRAEICKN GNKTKNRSHY SHESGEQKKK SVTEMQTNPP AEKKAVPAME KDSLGV
Target Information
PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Circadian clock protein PERIOD 2; hPER2; per2 {ECO:0000312|RGD:61945}; period 2; period circadian clock 2; period circadian protein 2; Period circadian protein homolog 2; period homolog 2; rPER2; unnamed protein product
Gene Aliases: FASPS; FASPS1; KIAA0347; PER2; rPER2
UniProt ID: (Human) O15055, (Rat) Q9Z301
Entrez Gene ID: (Human) 8864, (Rat) 63840
transcription regulatory region sequence-specific DNA binding
transcription corepressor binding
transcription coactivator activity
protein binding
transcription factor activity, transcription factor binding
core promoter binding
signal transducer activity
kinase binding
nuclear hormone receptor binding
pre-mRNA binding
histone deacetylase binding
ubiquitin binding
RNA polymerase binding
histone methyltransferase binding
transcription cofactor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
response to ischemia
neural retina development
glycogen biosynthetic process
gluconeogenesis
chromatin remodeling
fatty acid metabolic process
circadian rhythm
regulation of vasoconstriction
lactate biosynthetic process
negative regulation of protein ubiquitination
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of circadian rhythm
entrainment of circadian clock by photoperiod
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
regulation of neurogenesis
regulation of insulin secretion
white fat cell differentiation
regulation of cell cycle
regulation of glutamate uptake involved in transmission of nerve impulse
negative regulation of fat cell proliferation
positive regulation of cold-induced thermogenesis
transcription, DNA-templated
signal transduction
negative regulation of DNA-templated transcription, termination
histone H3 deacetylation
circadian regulation of translation
negative regulation of transcription regulatory region DNA binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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