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Invitrogen
PER3 Polyclonal Antibody
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FIGURE: 1 / 2
PER3 Antibody (PA5-119779) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of PER3 in MG-63 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with PER3 Polyclonal Antibody (Product # PA5-119779) at a dilution of 1:200 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue).
Product Details
PA5-119779
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human PER3 aa 1-200
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Mouse pancreas tissue lysate, Jurkat cell lysate, rat brain tissue lysate, MG-63.
Subcellular Location: Cytoplasm, Nucleus.
Target Information
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; hPER3; mPER3; period circadian clock 3; period circadian protein 3; Period circadian protein homolog 3; period homolog 3; rPER3; unnamed protein product
Gene Aliases: 2810049O06Rik; FASPS3; GIG13; mPer3; PER3; period3; rper3
UniProt ID: (Human) P56645, (Mouse) O70361, (Rat) Q8CJE2
Entrez Gene ID: (Human) 8863, (Mouse) 18628, (Rat) 78962
negative regulation of transcription from RNA polymerase II promoter
circadian rhythm
circadian regulation of gene expression
entrainment of circadian clock by photoperiod
regulation of circadian sleep/wake cycle, sleep
rhythmic process
protein stabilization
transcription, DNA-templated
regulation of transcription, DNA-templated
signal transduction
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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