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Fabgennix

PERK Polyclonal Antibody

View all (33) PERK antibodies

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PERK Polyclonal Antibody

Product Details

PERK-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Dot blot (DB)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.11.1; eIF-2 protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; pancreatic eIF-2 alpha kinase; pancreatic eIF-2alpha kinase; Pancreatic eIF2-alpha kinase; PKR-like ER kinase; PRKR-like endoplasmic reticulum kinase; Protein tyrosine kinase EIF2AK3; unnamed protein product

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Gene Aliases: AI427929; EIF2AK3; PEK; PERK; WRS

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UniProt ID: (Human) Q9NZJ5, (Rat) Q9Z1Z1, (Mouse) Q9Z2B5

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Entrez Gene ID: (Human) 9451, (Rat) 29702, (Mouse) 13666

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity enzyme binding protein phosphatase binding identical protein binding translation regulator activity misfolded protein binding Hsp90 protein binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups eukaryotic initiation factor eIF2 binding non-receptor serine/threonine protein kinase
Process(es)
skeletal system development ossification angiogenesis chondrocyte development translational initiation regulation of translation regulation of translational initiation response to oxidative stress ER overload response response to unfolded protein endoplasmic reticulum organization positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of translation calcium-mediated signaling bone mineralization endoplasmic reticulum unfolded protein response endocrine pancreas development negative regulation of myelination negative regulation of translation in response to stress negative regulation of translational initiation in response to stress cellular response to amino acid starvation response to endoplasmic reticulum stress regulation of translation initiation in response to endoplasmic reticulum stress PERK-mediated unfolded protein response cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of transcription from RNA polymerase I promoter negative regulation of translational initiation insulin-like growth factor receptor signaling pathway cellular response to cold mitochondrial respiratory chain supercomplex assembly positive regulation of protein localization to nucleus regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to manganese-induced endoplasmic reticulum stress translation protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process lactation positive regulation of signal transduction negative regulation of gene expression regulation of translational initiation by eIF2 alpha phosphorylation regulation of fatty acid metabolic process pancreas development positive regulation of protein binding SREBP signaling pathway negative regulation of apoptotic process fat cell differentiation protein autophosphorylation protein homooligomerization intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway phosphorylation peptidyl-serine phosphorylation negative regulation of translation in response to endoplasmic reticulum stress positive regulation of glutathione biosynthetic process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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