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Product Details
PA5-115738
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human PERP(Accession Q96FX8), corresponding to amino acid residues K50-Y71. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2900373 |
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1110017A08Rik; HGNC:17637; KCP-1; keratinocyte associated protein 1; Keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; p53 apoptosis-associated target; P53-induced protein PIGPC1; RP3-496H19.1; Transmembrane protein THW
Gene Aliases: 1110017A08Rik; dJ496H19.1; KCP1; KRTCAP1; PERP; PIGPC1; THW
UniProt ID: (Human) Q96FX8, (Mouse) Q9JK95
Entrez Gene ID: (Human) 64065, (Mouse) 64058
desmosome organization
Notch signaling pathway
heterotypic cell-cell adhesion
regulation of apoptotic process
positive regulation of proteolysis
intrinsic apoptotic signaling pathway by p53 class mediator
amelogenesis
activation of cysteine-type endopeptidase activity
cell-cell adhesion
apoptotic process
cell adhesion
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