Search
Bioss
PEX5 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
PEX5 Antibody (BS-12624R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with PEX5 Polyclonal Antibody, Unconjugated (bs-12624R) at 1:400 overnight at 4°C, DAB staining.
Product Details
BS-12624R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PEX5, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: peroxin 5; Peroxin-5; peroxisomal biogenesis factor 5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal import receptor 5; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; PXR1P; unnamed protein product
Gene Aliases: AW212715; ESTM1; PBD2A; PBD2B; PEX5; Pex5_predicted; PTS1-BP; PTS1R; PXR1; RCDP5; X83306
UniProt ID: (Human) P50542, (Mouse) O09012, (Rat) Q2M2R8
Entrez Gene ID: (Human) 5830, (Mouse) 19305, (Rat) 312703
peroxisome targeting sequence binding
peroxisome matrix targeting signal-1 binding
protein binding
enzyme binding
small GTPase binding
peroxisome membrane targeting sequence binding
protein carrier chaperone
protein C-terminus binding
protein N-terminus binding
molecular_function
membrane trafficking regulatory protein
very long-chain fatty acid metabolic process
pexophagy
neuron migration
protein monoubiquitination
protein targeting to peroxisome
lipid metabolic process
fatty acid beta-oxidation
mitochondrion organization
mitochondrial membrane organization
endoplasmic reticulum organization
peroxisome organization
protein transport
protein import into peroxisome matrix
protein import into peroxisome matrix, docking
protein import into peroxisome matrix, translocation
protein import into peroxisome matrix, receptor recycling
cerebral cortex cell migration
cerebral cortex neuron differentiation
negative regulation of protein complex assembly
cellular response to reactive oxygen species
positive regulation of multicellular organism growth
protein unfolding
protein import into peroxisome matrix, substrate release
protein import into peroxisome membrane
cell development
neuromuscular process
protein tetramerization
transport
isoprenoid biosynthetic process
cellular lipid metabolic process
negative regulation of protein homotetramerization
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support