Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).
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Protein Aliases: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; PF-4; Platelet factor 4
Gene Aliases: Cxcl4; PF-4; Pf4; Pf4a; RATPF4A; Scyb4