PA5-29363 targets PFKFB1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29363 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 194 of Human PFKFB1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.
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Protein Aliases: 2-kinase:fructose-2; 6-bisphosphatase; 6-P2ase 1; 6-P2ASE liver isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; F6PK; Fructose-2,6-bisphosphatase; fructose-6-phosphate; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; HL2K; PFK/FBPase 1; PFRX
Gene Aliases: F6PK; HL2K; PFKFB1; PFRX
UniProt ID: (Human) P16118
Entrez Gene ID: (Human) 5207