Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 20 publications 20 publications |
Immunohistochemistry (IHC) |
- | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | View 2 publications 2 publications |
Immunoprecipitation (IP) |
0.5-4.0 µg | View 1 publication 1 publication |
Miscellaneous PubMed (Misc) |
- | View 2 publications 2 publications |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PFKFB3-Specific Fusion Protein Ag4744 (243-520 aa encoded by BC040482) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
This antibody is specific to PFKFB3.
Immunogen sequence: HVQPRTIYL CRHGENEHNL QGRIGGDSGL SSRGKKFASA LSKFVEEQNL KDLRVWTSQL KSTIQTAEAL RLPYEQWKAL NEIDAGVCEE LTYEEIRDTY PEEYALREQD KYYYRYPTGE SYQDLVQRLE PVIMELERQE NVLVICHQAV LRCLLAYFLD KSAEEMPYLK CPLHTVLKLT PVAYGCRVES IYLNVESVCT HRERSEDAKK GPNPLMRRNS VTPLASPEPT KKPRINSFEE HVASTSAALP SCLPPEVPTQ LPGQNMKGSR SSADSSRKH (243-520 aa encoded by BC040482)
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6-biphosphatase 3; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Fructose-2; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; PFK/FBPase 3; RB2K; Renal carcinoma antigen NY-REN-56; RP11-298K24.3
Gene Aliases: E330010H22Rik; iPFK-2; IPFK2; PFK2; PFKFB3; uPFK-2
UniProt ID: (Human) Q16875, (Rat) Q9QWQ6
Entrez Gene ID: (Human) 5209, (Rat) 117276, (Mouse) 170768
Molecular Function:
carbohydrate phosphatase
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