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Proteintech
PFTK1 Polyclonal Antibody
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Product Details
21612-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PFTK1 Fusion Protein Ag16259 (303-451 aa encoded by BC136477)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to PFTK1.
Immunogen sequence: IFVEMIQGV AAFPGMKDIQ DQLERIFLVL GTPNEDTWPG VHSLPHFKPE RFTLYSSKNL RQAWNKLSYV NHAEDLASKL LQCSPKNRLS AQAALSHEYF SDLPPRLWEL TDMSSIFTVP NVRLQPEAGE SMRAFGKNNS YGKSLSNSKH (303-451 aa encoded by BC136477)
Target Information
CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with esophageal squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cell division protein kinase 14; Cyclin-dependent kinase 14; hPFTAIRE1; PFTAIRE protein kinase 1; Serine/threonine-protein kinase PFTAIRE-1; unnamed protein product
Gene Aliases: CDK14; KIAA0834; mKIAA0834; PFTAIRE1; PFTK1
UniProt ID: (Human) O94921, (Mouse) O35495
Entrez Gene ID: (Human) 5218, (Rat) 362316, (Mouse) 18647
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
cyclin binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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