Proteintech

PGAM2 Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (23)

PGAM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 23

PGAM2 Antibody (15550-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 15550-1-AP) (PGAM2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

15550-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PGAM2 Fusion Protein Ag7908 (1-253 aa encoded by BC001904)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATHRLVMV RHGESTWNQE NRFCGWFDAE LSEKGTEEAK RGAKAIKDAK MEFDICYTSV LKRAIRTLWA ILDGTDQMWL PVVRTWRLNE RHYGGLTGLN KAETAAKHGE EQVKIWRRSF DIPPPPMDEK HPYYNSISKE RRYAGLKPGE LPTCESLKDT IARALPFWNE EIVPQIKAGK RVLIAAHGNS LRGIVKHLEG MSDQAIMELN LPTGIPIVYE LNKELKPTKP MQFLGDEETV RKAMEAVAAQ GKAK (1-253 aa encoded by BC001904)

Target Information

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). PGAM2 encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase efficiency, also known as glycogen storage disease X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lactate metabolism is essential in early-onset mitochondrial myopathy.

Science advances

Chen Z,Bordieanu B,Kesavan R,Lesner NP,Venigalla SSK,Shelton SD,DeBerardinis RJ,Mishra P

Wed Jan 04 00:00:00 EST 2023

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

EMBO reports

Hou Y,Zhang X,Yao H,Hou L,Zhang Q,Tao E,Zhu X,Jiang S,Ren Y,Hong X,Lu S,Leng X,Xie Y,Gao Y,Liang Y,Zhong T,Long B,Fang JY,Meng X

Wed Apr 05 00:00:00 EDT 2023

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

EMBO reports

Hou Y,Zhang X,Yao H,Hou L,Zhang Q,Tao E,Zhu X,Jiang S,Ren Y,Hong X,Lu S,Leng X,Xie Y,Gao Y,Liang Y,Zhong T,Long B,Fang JY,Meng X

Wed Apr 05 00:00:00 EDT 2023

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

EMBO reports

Hou Y,Zhang X,Yao H,Hou L,Zhang Q,Tao E,Zhu X,Jiang S,Ren Y,Hong X,Lu S,Leng X,Xie Y,Gao Y,Liang Y,Zhong T,Long B,Fang JY,Meng X

Wed Apr 05 00:00:00 EDT 2023

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

EMBO reports

Hou Y,Zhang X,Yao H,Hou L,Zhang Q,Tao E,Zhu X,Jiang S,Ren Y,Hong X,Lu S,Leng X,Xie Y,Gao Y,Liang Y,Zhong T,Long B,Fang JY,Meng X

Wed Apr 05 00:00:00 EDT 2023

Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility.

Journal of proteomics

Guo Y,Jiang W,Yu W,Niu X,Liu F,Zhou T,Zhang H,Li Y,Zhu H,Zhou Z,Sha J,Guo X,Chen D

Mon Sep 30 00:00:00 EDT 2019

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Scientific reports

Fu L,Xu Y,Hou Y,Qi X,Zhou L,Liu H,Luan Y,Jing L,Miao Y,Zhao S,Liu H,Li X

Mon Mar 27 00:00:00 EDT 2017

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Scientific reports

Fu L,Xu Y,Hou Y,Qi X,Zhou L,Liu H,Luan Y,Jing L,Miao Y,Zhao S,Liu H,Li X

Mon Mar 27 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; PGAM-M; Phosphoglycerate mutase 2; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase isozyme M; phosphoglycerate mutase muscle-specific subunit

View more View less

Gene Aliases: GSD10; PGAM-M; PGAM2; PGAMM

View more View less

UniProt ID: (Human) P15259, (Mouse) O70250

View more View less

Entrez Gene ID: (Human) 5224, (Mouse) 56012

View more View less

Function(s)

bisphosphoglycerate mutase activity bisphosphoglycerate 2-phosphatase activity phosphoglycerate mutase activity 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity cofactor binding catalytic activity protein binding hydrolase activity isomerase activity intramolecular transferase activity, phosphotransferases mutase

Process(es)

gluconeogenesis glycolytic process striated muscle contraction Notch signaling pathway spermatogenesis dephosphorylation regulation of pentose-phosphate shunt response to mercury ion canonical glycolysis metabolic process response to inorganic substance

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

PGAM2 Polyclonal Antibody

PGAM2 Antibody (15550-1-AP) in IHC (P)

Product Details

15550-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!