Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). PGAM2 encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase efficiency, also known as glycogen storage disease X.
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Protein Aliases: BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; PGAM-M; Phosphoglycerate mutase 2; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase isozyme M; phosphoglycerate mutase muscle-specific subunit
Gene Aliases: GSD10; PGAM-M; PGAM2; PGAMM
Molecular Function: mutase